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There are limited controlled data in human pregnancy. Levomilnacipran: CYP3A4 Inhibitors Strong may increase the serum concentration of Levomilnacipran. When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing. 1 In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy. Estimates of the rate of human CYP3A4 vary widely. For hepatic CYP3A4, in vivo methods yield estimates of enzyme mainly in the range of 70 to 140 hours, whereas in vitro methods give estimates from 26 to 79 hours.

Benson CA MAC: pathogenesis and treatment

Pichichero ME, Cohen R. Shortened course of antibiotic therapy for acute otitis media, sinusitis and tonsillopharyngitis. Amoxicillin and clarithromycin pass into milk. It is unknown if lansoprazole passes into milk. Consult your doctor before breast-feeding. The use of vitamin K 1 reduces response to subsequent Coumadin therapy and patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged INR. Resumption of Coumadin administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment. If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy.

Clarithromycin uses

Bilberry is also used for treating conditions such as and disorders of the retina. There is some evidence that bilberry may help retinal disorders. This medication passes into milk. Consult your doctor before -feeding. Hypersensitivity reactions: Severe acute reactions have been reported, including anaphylaxis, Stevens-Johnson syndrome SJS toxic epidermal necrolysis TEN drug rash with eosinophilia and systemic symptoms DRESS and Henoch-Schönlein purpura IgA vasculitis; discontinue therapy and initiate treatment immediately for severe acute hypersensitivity reactions. Bordetella bacteria. However, by the time the cough becomes severe and pertussis typically diagnosed, antibiotic therapy may be too late to relieve the symptoms.

Clarithromycin dosing information

Patients with disseminated MAC disease should continue chronic maintenance therapy secondary prophylaxis unless immune reconstitution occurs due to ART. Dosage adjustment for concomitant therapy: Atazanavir: Decrease clarithromycin dose by 50%. PrednisoLONE Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of PrednisoLONE Systemic.



Klein JO Otitis Media

Bottles of 60 NDC 68382-763-14. Adolescents: Refer to adult dosing. For a given patient, H. pylori was considered eradicated if at least two of these tests were negative, and none was positive. The combination of Clarithromycin plus omeprazole and amoxicillin was effective in eradicating H. pylori see results in Table 19. Fennerty MB. “Cure” of Helicobacter pylori: clinically indicated and economically wise! Repaglinide: Macrolide Antibiotics may increase the serum concentration of Repaglinide. This medication is not usually used in women. Therefore, it is unlikely to be used during or -feeding. Consult your doctor if you have any questions about this medication. Be sure to use clarithromycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Astemizole: CYP3A4 Inhibitors Strong may increase the serum concentration of Astemizole.



Use of clarithromycin

Abbott Laboratories. Norvir ritonavir capsules and oral solution prescribing information. North Chicago, IL; 2000 Dec. Chirgwin K, Roblin PM, Hammerschlag MR. In vitro susceptibilities of Chlamydia pneumoniae Chlamydia sp. strain TWAR. Antimicrob Agents Chemother. Clarithromycin extended-release tablets provide extended absorption of Clarithromycin from the gastrointestinal tract after oral administration. Relative to an equal total daily dose of immediate-release Clarithromycin tablets, Clarithromycin extended-release tablets provide lower and later steady-state peak plasma concentrations but equivalent 24-hour AUCs for both Clarithromycin and its microbiologically-active metabolite, 14-OH Clarithromycin. While the extent of formation of 14-OH Clarithromycin following administration of Clarithromycin Extended-Release Tablets 2 x 500 mg tablets once daily is not affected by food, administration under fasting conditions is associated with approximately 30% lower Clarithromycin AUC relative to administration with food. Therefore, Clarithromycin Extended-Release Tablets should be taken with food. The supplied Clarithromycin for Oral Suspension, USP must be reconstituted with water prior to administration of Clarithromycin for oral suspension. Table 3 below indicates the volume of water to be added when reconstituting. Dry your hands before handling this medication. Remove the dose from the package right before use. Place the tablet on your and allow it to dissolve completely. Do not crush or split the tablet. This medication should not be taken with liquid. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. IV in divided doses every 6 hours or by continuous infusion. Warfarin reduces the regeneration of vitamin K from vitamin K epoxide in the vitamin K cycle through inhibition of VKOR, a multiprotein enzyme complex. Olaparib: CYP3A4 Inhibitors Strong may increase the serum concentration of Olaparib. Management: Avoid use of strong CYP3A4 inhibitors in patients being treated with olaparib. If such concurrent use cannot be avoided, the dose of olaparib should be reduced to 150 mg twice daily. Read the Patient Information Leaflet provided by your before you start taking vardenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Ado-Trastuzumab Emtansine: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Ado-Trastuzumab Emtansine. Specifically, strong CYP3A4 inhibitors may increase concentrations of the cytotoxic DM1 component. Simultaneous administration of Clarithromycin tablets and didanosine to 12 HIV-infected adult patients resulted in no statistically significant change in didanosine pharmacokinetics. This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case. Most isolates of methicillin-resistant and oxacillin-resistant staphylococci are resistant to Clarithromycin. Exercise caution when prescribing clarithromycin with atorvastatin or pravastatin. In situations where the concomitant use of clarithromycin with atorvastatin or pravastatin cannot be avoided, atorvastatin dose should not exceed 20 mg daily and pravastatin dose should not exceed 40 mg daily. These trials compared the combination regimen to omeprazole and Clarithromycin monotherapies. Trials 14 and 15were conducted in Europe and enrolled 154 and 215 patients, respectively. glimepiride



Clarithromycin adult dosage

Complete cross-resistance occurs between azithromycin and clarithromycin in MAC. Liquid products may contain sugar. Caution is advised if you have or any other condition that requires you to limit sugar in your diet. Ask your doctor or pharmacist about using this product safely. Effect of TE-031 A-56268 a new oral macrolide antibiotic, on serum theophylline concentration. Hanson CW, Bailer R, Gade E et al. Regression analysis, proposed interpretative zone size standards, and quality control guidelines for a new macrolide antimicrobial agent, A-56268 TE-031. J Clin Microbiol. Get emergency medical help if you have any signs of an allergic reaction to Movantik: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Malfertheiner P. Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. Scand J Gastroenterol Suppl. The rate ratio is for aspirin plus warfarin as compared with aspirin. Colchicine: CYP3A4 Inhibitors Strong may increase the serum concentration of Colchicine. Management: Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a strong CYP3A4 inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed. In a steady-state study in which healthy elderly subjects 65 years to 81 years of age were given 500 mg of clarithromycin every 12 hours, the maximum serum concentrations and area under the curves of clarithromycin and 14-OH clarithromycin were increased compared to those achieved in healthy young adults. These changes in pharmacokinetics parallel known age-related decreases in renal function. In clinical trials, elderly patients did not have an increased incidence of adverse reactions when compared to younger patients. Consider dosage adjustment in elderly patients with severe renal impairment. Fennerty MB. Helicobacter pylori. Ann Intern Med. Monitoring the patient for increased CNS pharmacological effects is suggested. In postmarketing experience, erythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines. Other co-inherited VKORC1 variants may also be important determinants of warfarin dose. finasteride pharmacy usa finasteride



CYP3A inhibitors such as clarithromycin

Eszopiclone: CYP3A4 Inhibitors Strong may increase the serum concentration of Eszopiclone. Management: Limit the eszopiclone dose to 2 mg daily when combined with strong CYP3A4 inhibitors and monitor for increased eszopiclone effects and toxicities eg, somnolence, drowsiness, CNS depression. Mandell LA, Bartlett JG, Dowell SF et al. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis. OH Clarithromycin AUC and C max decreased 24% and 34% respectively, compared to administration with Clarithromycin alone. In two other controlled clinical trials of acute otitis media performed in the United States, where significant rates of beta-lactamase producing organisms were found, clarithromycin was compared to an oral antimicrobial agent that contained a specific beta-lactamase inhibitor. In these trials, strict evaluability criteria were used to determine the clinical responses. Coumadin is contraindicated in any unsupervised patient with senility. Observe caution with administration of Coumadin to elderly patients in any situation or with any physical condition where added risk of hemorrhage is present. Shake the bottle well before each dose. Fraschini F, Scaglione F, Pintucci G et al. The diffusion of clarithromycin and roxithromycin into nasal mucosa, tonsil and lung in humans. J Antimicrob Chemother. Sandoz. Lescol fluvastatin sodium capsules prescribing information. East Hanover, NJ: 1996 Mar. BusPIRone: Macrolide Antibiotics may decrease the metabolism of BusPIRone. TAP Pharmaceuticals. PrevPac lansoprazole 30-mg capsules, amoxicillin 500-mg capsules, and clarithromycin 500-mg tablets prescribing information. Deerfield, IL; 1997 Dec. Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. CDC, AAP, IDSA, AHA, and others recommend oral penicillin V or IM penicillin G benzathine as treatments of choice; 107 109 110 396 oral cephalosporins and oral macrolides considered alternatives. 107 109 110 396 Amoxicillin sometimes used instead of penicillin V, especially for young children. Since this drug can be absorbed through the and may harm an unborn baby, women who are or who may become pregnant should not handle this medication. Conivaptan: CYP3A4 Inhibitors Strong may increase the serum concentration of Conivaptan. Adverse events have been documented in some animal reproduction studies. Clarithromycin crosses the placenta Witt 2003. The manufacturer recommends that clarithromycin not be used in a pregnant woman unless there are no alternative therapies. Clarithromycin Extended-Release Tablets should be taken with food. Swallow Clarithromycin Extended-Release Tablets whole; do not chew, break or crush Clarithromycin Extended-Release Tablets.



Common side effects of clarithromycin

Erythromycin is recommended by the American Heart Association for long-term prophylaxis of streptococcal upper respiratory tract infections in the prevention of recurrences of rheumatic fever in patients allergic to penicillin and sulfonamides. This may not be a complete list of all interactions that may occur. Ask your health care provider if clarithromycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Clarithromycin may cause live bacterial such as to not work as well. Committee on Infectious Diseases, American Academy of Pediatrics. Red book: 2003 report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2003. Yeung CK, Fu KH, Yuen KY et al. Helicobacter pylori and associated duodenal ulcer. Arch Dis Child. estreva pm cost estreva



Clarithromycin dosage

Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica. These zone diameter standards are applicable only to tests with Haemophilus spp. Minor bleeding episodes were defined as non-cerebral hemorrhage not necessitating surgical intervention or blood transfusion. Bachand RT Jr. Comparative study of clarithromycin and ampicillin in the treatment of patients with acute bacterial exacerbations of chronic bronchitis. J Antimicrob Chemother. Parsonnet J, Friedman GD, Vandersteen DP et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. Twelfth Edition. CLSI document M02-A12, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. The combination of this drug and rifabutin should not be used for primary MAC prophylaxis; not more effective than this drug alone. Facts for prescribers Fakta för förskrivare. Goodwin CS. Duodenal ulcer, Campylobacter pylori, and the “leaking roof” concept. Lancet. Some medications that slow blood clotting include aspirin, clopidogrel Plavix diclofenac Voltaren, Cataflam, others ibuprofen Advil, Motrin, others naproxen Anaprox, Naprosyn, others dalteparin Fragmin enoxaparin Lovenox heparin, warfarin Coumadin and others. This information is generalized and not intended as specific medical advice. Nightingale SD, Koster FT, Mertz GJ et al. Clarithromycin-induced mania in two patients with AIDS. Clin Infect Dis. Prothrombin complex concentrate PCC fresh frozen plasma, or activated Factor VII treatment may be considered if the requirement to reverse the effects of Coumadin is urgent. A risk of hepatitis and other viral diseases is associated with the use of blood products; PCC and activated Factor VII are also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to Coumadin overdosage. price of albenza in ireland



What other drugs will affect clarithromycin

Mor N, Heifets L. MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. Antimicrob Agents Chemother. Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake "-driving". Lietti A, Cristoni A, Picci M. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Crystalline warfarin sodium occurs as a white, odorless, crystalline powder that is discolored by light. It is very soluble in water, freely soluble in alcohol, and very slightly soluble in chloroform and ether. ABCB1 Inhibitors may increase the serum concentration of Colchicine. Graham DY, Lew GM, Evans DG et al. Effect of triple therapy antibiotics plus bismuth on duodenal ulcer healing: a randomized controlled trial. Ann Intern Med. The effects of your digoxin may increase and cause a slow or irregular heartbeat. DOSAGE: See package insert. Steere AC. Lyme disease. N Engl J Med. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. The results for trial 1 are described below. Cassell GH, Drnec J, Waites KB et al. Efficacy of clarithromycin against Mycoplasma pneumoniae. J Antimicrob Chemother. Other medications can affect the removal of vardenafil from your body, which may affect how vardenafil works. When 250 mg doses of clarithromycin for oral suspension were administered to fasting healthy adult subjects, peak plasma concentrations were attained around 3 hours after dosing. When 250 mg doses of Clarithromycin as an oral suspension were administered to fasting healthy adult subjects, peak plasma concentrations were attained around 3 hours after dosing. Some medications used for diabetes include glimepiride Amaryl glyburide DiaBeta, Glynase PresTab, Micronase insulin, pioglitazone Actos rosiglitazone Avandia chlorpropamide Diabinese glipizide Glucotrol tolbutamide Orinase and others.



Clarithromycin forms and strengths

This helps to relieve symptoms of such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently including during the middle of the night. The major routes of resistance are modification of the 23S rRNA in the 50S ribosomal subunit to insensitivity or drug efflux pumps. Beta-lactamase production should have no effect on Clarithromycin activity. Counsel patients that antibacterial drugs including Clarithromycin should only be used to treat bacterial infections. Fatal and serious calciphylaxis or calcium uremic arteriolopathy has been reported in patients with and without end-stage renal disease. When calciphylaxis is diagnosed in these patients, discontinue Coumadin and treat calciphylaxis as appropriate. Consider alternative anticoagulation therapy. Clarithromycin and 14-hydroxyclarithromycin distributed into most body tissues and fluids 1 2 54 55 56 68 in concentrations greater than serum concentrations. Nilotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Nilotinib. MMWR Morb Mortal Wkly Rep. Alfentanil: Macrolide Antibiotics may increase the serum concentration of Alfentanil. Management: For patients receiving an interacting macrolide antibiotic, caution should be used in administering alfentanil; monitor for increased anesthetic and respiratory depressant effects. Consider using lower doses of alfentanil or an alternative anesthetic. Doxercalciferol: CYP3A4 Inhibitors Strong may decrease serum concentrations of the active metabolites of Doxercalciferol. price condylox manufacturer



General information about clarithromycin

Vardenafil is used to treat male sexual function problems impotence or -ED. In combination with sexual stimulation, vardenafil works by increasing flow to the to help a man get and keep an erection. Exercise caution when prescribing Clarithromycin with atorvastatin or pravastatin. In situations where the concomitant use of Clarithromycin with atorvastatin or pravastatin cannot be avoided, atorvastatin dose should not exceed 20 mg daily and pravastatin dose should not exceed 40 mg daily. Red Yeast Rice: CYP3A4 Inhibitors Strong may increase the serum concentration of Red Yeast Rice. Specifically, concentrations of lovastatin and related compounds found in Red Yeast Rice may be increased. Talley NJ, Zinsmeister AR, Weaver A et al. Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst. MedroxyPROGESTERone: CYP3A4 Inhibitors Strong may increase the serum concentration of MedroxyPROGESTERone. Your doctor will order blood tests to monitor for this. Keep all medical appointments. For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of clarithromycin is 500 mg every 12 hours. ffix.info careprost



Clarithromycin consumer information

Dronabinol: CYP3A4 Inhibitors Strong may increase the serum concentration of Dronabinol. Kinoshita, J. H. Diabetic cataracts and flavonoids. Regorafenib: CYP3A4 Inhibitors Strong may increase the serum concentration of Regorafenib. Valleé E, Azoulay-Dupuis E, Swanson R et al. Individual and combined activities of clarithromycin and its 14-hydroxy metabolite in a murine model of Haemophilus influenzae infection. J Antimicrob Chemother. Levobupivacaine: CYP3A4 Inhibitors Strong may increase the serum concentration of Levobupivacaine. Infants and children receiving vitamin K-supplemented nutrition, including infant formulas, may be resistant to warfarin therapy, while human milk-fed infants may be sensitive to warfarin therapy. Do not take this medication with alcohol, or if you have had alcohol that day, especially in the evening before bed. Clarithromycin is available as granules for oral suspension. Dautzenberg B, St. Marc T, Averous V et al. Clarithromycin-containing regimens in the treatment of 54 AIDS patients with disseminated Mycobacterium avium intracellulare infection. Proceedings of ICAAC Chicago 1991. Abstract No. 293. There have been postmarketing reports of hypoglycemia with the concomitant administration of Clarithromycin and disopyramide. Therefore, blood glucose levels should be monitored during concomitant administration of Clarithromycin and disopyramide. Exacerbation of symptoms of myasthenia gravis and new onset of symptoms of myasthenic syndrome has been reported in patients receiving Clarithromycin therapy. Manidipine: CYP3A4 Inhibitors Strong may increase the serum concentration of Manidipine. Management: Consider avoiding concomitant use of manidipine and strong CYP3A4 inhibitors. If combined, monitor closely for increased manidipine effects and toxicities. Manidipine dose reductions may be required. Soriano V, Dona C, Rodriguez-Rosado R et al. Discontinuation of secondary prophylaxis for opportunistic infections in HIV-infected patients receiving highly active antiretroviral therapy. AIDS.



How should i take clarithromycin

The terminal half-life of warfarin after a single dose is approximately 1 week; however, the effective half-life ranges from 20 to 60 hours, with a mean of about 40 hours. The clearance of R-warfarin is generally half that of S-warfarin, thus as the volumes of distribution are similar, the half-life of R-warfarin is longer than that of S-warfarin. The half-life of R-warfarin ranges from 37 to 89 hours, while that of S-warfarin ranges from 21 to 43 hours. Studies with radiolabeled drug have demonstrated that up to 92% of the orally administered dose is recovered in urine. Very little warfarin is excreted unchanged in urine. Urinary excretion is in the form of metabolites. Cabozantinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Cabozantinib. Management: Avoid use of a strong CYP3A4 inhibitor with cabozantinib if possible. If combined, cabozantinib dose adjustments are recommended and vary based on the cabozantinib product used and the indication for use. See monograph for details. Eliopoulos GM, Reiszner E, Ferraro MJ et al. Comparative in-vitro activity of A-56268 TE-031 a new macrolide antibiotic. J Antimicrob Chemother. CYP3A4 is absent in fetal liver but increases to approximately 40% of adult levels in the fourth month of life and 72% at 12 months. Immediate-release 250 mg tablets: Store at controlled room temperature 15C to 30C 59F to 86F in a well-closed container; protect from light. order cheap citalopram pharmacy europe



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What are the possible side effects of clarithromycin


Decrease clarithromycin dose by 50%

Dytoc MT, Honish L, Shandro C et al. Clinical, microbiological, and epidemiological findings of an outbreak of Mycobacterium abscessus hand-and-foot disease. Diagn Microbiol Infect Dis. 2005. In press. Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med. Second Edition. CLSI document M45-A2, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2010. Shake the oral solution well before each use. purchase generic cetirizine payment usa

Side effects of clarithromycin

Clarithromycin Tablets, USP is given in combination with other drugs in adults as described below to eradicate H. pylori. Read the Guide provided by your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Coumadin can cause fetal harm when administered to a pregnant woman. While Coumadin is contraindicated during pregnancy, the potential benefits of using Coumadin may outweigh the risks for pregnant women with mechanical heart valves at high risk of thromboembolism. Clarithromycin Tablets, USP and Clarithromycin for Oral Suspension, USP are indicated for the treatment of mild to moderate infections caused by susceptible isolates due to Staphylococcus aureus, or Streptococcus pyogenes.

Zidovudine is not a cure for HIV infection

Shafran SD, Singer J, Zarowny DP et al. Determinants of rifabutin-associated uveitis in patients treated with rifabutin, clarithromycin, and ethambutol for Mycobacterium avium complex bacteremia: a multivariate analysis. Canadian HIV Trials Network Protocol 010 Study Group. J Infect Dis. The low levels in milk are unlikely to cause harmful effects in the nursing infant. The infant should be monitored for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash. According to unconfirmed epidemiologic evidence, maternal macrolide use during breastfeeding may increase the risk of hypertrophic pyloric stenosis in infants. minocin

Clarithromycin brand names

Decreases in MAC bacteremia or negative blood cultures were seen in the majority of patients in clarithromycin. Infectious Diseases Society of America. MMWR Morb Mortal Wkly Rep. 2004; 53No. Morimoto S, Nagate T, Sugita K et al. Chemical modification of erythromycins. III. In vitro and in vivo antibacterial activities of new semisynthetic 6- O-methylerythromycins A, TE-031 clarithromycin and TE-032. J Antibiot Tokyo.

Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus VMA on platelet aggregation and adhesiveness. The longer patients with COPD or pneumonia used clarithromycin, the greater their risk of more heart problems. The treatment of excessive anticoagulation is based on the level of the INR, the presence or absence of bleeding, and clinical circumstances. metaglip

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